解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Olfaction is a versatile sensory mechanism for detecting thousands of volatile odorants. Although molecular basis of odorant signaling is relatively well understood considerable gaps remain in the complete charting of all relevant gene products. To address this challenge, we applied RNAseq to four well-chara...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2960-3
更新日期:2016-08-11 00:00:00
abstract:BACKGROUND:Ramularia collo-cygni is a newly important, foliar fungal pathogen of barley that causes the disease Ramularia leaf spot. The fungus exhibits a prolonged endophytic growth stage before switching life habit to become an aggressive, necrotrophic pathogen that causes significant losses to green leaf area and he...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2928-3
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Meiotic recombination is a fundamental evolutionary process. It not only generates diversity, but influences the efficacy of natural selection and genome evolution. There can be significant heterogeneity in recombination rates within and between species, however this variation is not well understood outside ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2884-y
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Zoysia matrella, widely used in lawns and sports fields, is of great economic and ecological value. Z. matrella is an allotetraploid species (2n = 4x = 40) in the genus zoysia under the subfamily Chloridoideae. Despite its ecological impacts and economic importance, the subfamily Chloridoideae has received l...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2969-7
更新日期:2016-08-08 00:00:00
abstract:BACKGROUND:The spiral cleavage mode of early development is utilized in over one-third of all animal phyla and generates embryonic cells of different size, position, and fate through a conserved set of stereotypic and invariant asymmetric cell divisions. Despite the widespread use of spiral cleavage, regulatory and mol...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2860-6
更新日期:2016-08-05 00:00:00
abstract:BACKGROUND:The recent advances in next generation sequencing technology have made the sequencing of RNA (i.e., RNA-Seq) an extemely popular approach for gene expression analysis. Identification of significant differential expression represents a crucial initial step in these analyses, on which most subsequent inference...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2848-2
更新日期:2016-08-04 00:00:00
abstract:BACKGROUND:Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates. RESULTS:To enable functional analysis of human transposase-derived genes, we comb...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2877-x
更新日期:2016-08-04 00:00:00
abstract:BACKGROUND:The Lundehund is a highly specialized breed characterized by a unique flexibility of the joints and polydactyly in all four limbs. The extremely small population size and high inbreeding has promoted a high frequency of diseased dogs affected by the Lundehund syndrome (LS), a severe gastro-enteropathic disea...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2844-6
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:Cyanobacteria are major primary producers in extreme cold ecosystems. Many lineages of cyanobacteria thrive in these harsh environments, but it is not fully understood how they survive in these conditions and whether they have evolved specific mechanisms of cold adaptation. Phormidesmis priestleyi is a cyano...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2846-4
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:The technological revolution in next-generation sequencing has brought unprecedented opportunities to study any organism of interest at the genomic or transcriptomic level. Transcriptome assembly is a crucial first step for studying the molecular basis of phenotypes of interest using RNA-Sequencing (RNA-Seq)...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2923-8
更新日期:2016-07-27 00:00:00
abstract:BACKGROUND:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2785-0
更新日期:2016-06-29 00:00:00
abstract:BACKGROUND:The capsular polysaccharide is the principal virulence factor of Streptococcus pneumoniae and a target for current pneumococcal vaccines. However, some pathogenic pneumococci are serologically nontypeable [nontypeable pneumococci (NTPn)]. Due to their relative rarity, NTPn are poorly characterized, and, as s...
journal_title:BMC genomics
pub_type: 历史文章,杂志文章
doi:10.1186/s12864-016-2808-x
更新日期:2016-06-22 00:00:00
abstract:BACKGROUND:The sacred lotus (Nelumbo nucifera) is widely cultivated in China for its edible rhizomes and seeds. Traditional plant breeding methods have been used to breed cultivars with increased yields and quality of rhizomes and seeds with limited success. Currently, the available genetic maps and molecular markers i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2781-4
更新日期:2016-06-17 00:00:00
abstract:BACKGROUND:Genome-scale functional genomic screens across large cell line panels provide a rich resource for discovering tumor vulnerabilities that can lead to the next generation of targeted therapies. Their data analysis typically has focused on identifying genes whose knockdown enhances response in various pre-defin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2807-y
更新日期:2016-06-13 00:00:00
abstract:BACKGROUND:Sugarcane is a major sugar and biofuel crop, but genomic research and molecular breeding have lagged behind other major crops due to the complexity of auto-allopolyploid genomes. Sugarcane cultivars are frequently aneuploid with chromosome number ranging from 100 to 130, consisting of 70-80 % S. officinarum,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2817-9
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:MECP2, the gene mutated in the majority of Rett syndrome cases, is a transcriptional regulator that can activate or repress transcription. Although the transcription regulatory function of MECP2 has been known for over a decade, it remains unclear how transcriptional dysregulation leads to the neurodevelopme...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2746-7
更新日期:2016-06-06 00:00:00
abstract:BACKGROUND:Post-translational glycosylation of the flagellin protein is relatively common among Gram-negative bacteria, and has been linked to several phenotypes, including flagellar biosynthesis and motility, biofilm formation, host immune evasion and manipulation and virulence. However to date, despite extensive phys...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2735-x
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:Understanding how plants and pathogens modulate gene expression during the host-pathogen interaction is key to uncovering the molecular mechanisms that regulate disease progression. Recent advances in sequencing technologies have provided new opportunities to decode the complexity of such interactions. In th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2684-4
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:Hulless barley, also called naked barley, is an important cereal crop worldwide, serving as a healthy food both for human consumption and animal feed. Nevertheless, it often suffered from drought stress during its growth and development, resulting in a drastic reduction in barley yields. Therefore, study on ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2685-3
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:The P1B-ATPase subfamily is an important group involved in transporting heavy metals and has been extensively studied in model plants, such as Arabidopsis thaliana and Oryza sativa. Emerging evidence indicates that one homolog in Glycine max is also involved in cadmium (Cd) stress, but the gene family has no...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2730-2
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:Magnaporthe oryzae (anamorph Pyricularia oryzae) is the causal agent of blast disease of Poaceae crops and their wild relatives. To understand the genetic mechanisms that drive host specialization of M. oryzae, we carried out whole genome resequencing of four M. oryzae isolates from rice (Oryza sativa), one ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2690-6
更新日期:2016-05-18 00:00:00
abstract:BACKGROUND:The pathogenesis-related (PR) group of proteins are operationally defined as polypeptides that increase in concentration in plant tissues upon contact with a pathogen. To date, 17 classes of highly divergent proteins have been described that act through multiple mechanisms of pathogen resistance. Characteriz...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2693-3
更新日期:2016-05-17 00:00:00
abstract:BACKGROUND:Despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (CREs), DNA sequences that control gene expression, have been identified in mosquitoes or other non-model insects. Formaldehyde-assisted isolation of regulatory elements paired with DNA sequencing, FAIRE-seq, i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2468-x
更新日期:2016-05-10 00:00:00
abstract:BACKGROUND:Foxtail millet [Setaria italica (L.) P. Beauv.], a crop of historical importance in China, has been adopted as a model crop for studying C-4 photosynthesis, stress biology and biofuel traits. Construction of a high density genetic map and identification of stable quantitative trait loci (QTL) lay the foundat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2628-z
更新日期:2016-05-04 00:00:00
abstract:BACKGROUND:Low iron bioavailability is a common feature of ocean surface water and therefore micro-algae developed original strategies to optimize iron uptake and metabolism. The marine picoeukaryotic green alga Ostreococcus tauri is a very good model for studying physiological and genetic aspects of the adaptation of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2666-6
更新日期:2016-05-03 00:00:00
abstract:BACKGROUND:Cryptic unstable transcripts (CUTs) are a largely unexplored class of nuclear exosome degraded, non-coding RNAs in budding yeast. It is highly debated whether CUT transcription has a functional role in the cell or whether CUTs represent noise in the yeast transcriptome. We sought to ascertain the extent of c...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2622-5
更新日期:2016-04-26 00:00:00
abstract:BACKGROUND:Improving fiber quality is a major challenge in cotton breeding, since the molecular basis of fiber quality traits is poorly understood. Fine mapping and candidate gene prediction of quantitative trait loci (QTL) controlling cotton fiber quality traits can help to elucidate the molecular basis of fiber quali...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2605-6
更新日期:2016-04-19 00:00:00
abstract:BACKGROUND:Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially redu...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2612-7
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:Rich in genetic information and cost-effective to genotype, the Insertion-Deletion (InDel) molecular marker system is an important tool for studies in genetics, genomics and for marker-assisted breeding. Advent of next-generation sequencing (NGS) revolutionized the speed and throughput of sequence data gener...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2614-5
更新日期:2016-04-14 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) is a rapidly evolving RNA virus that has been classified into seven genotypes. All HCV genotypes cause chronic hepatitis, which ultimately leads to liver diseases such as cirrhosis. The genotypes are unevenly distributed across the globe, with genotypes 1 and 3 being the most prevalen...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2575-8
更新日期:2016-03-17 00:00:00
abstract:BACKGROUND:Hard ticks (family Ixodidae) are obligatory hematophagous ectoparasites of worldwide medical and veterinary importance. The haploid genomes of multiple species of ixodid ticks exceed 1 Gbp, prompting questions regarding gene, segmental and whole genome duplication in this phyletic group. The availability of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2350-2
更新日期:2016-03-16 00:00:00
abstract:BACKGROUND:Effector proteins are translocated into host cells by plant-pathogens to undermine pattern-triggered immunity (PTI), the plant response to microbe-associated molecular patterns that interferes with the infection process. Individual effectors are found in variable repertoires where some constituents target th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2534-4
更新日期:2016-03-14 00:00:00
abstract:BACKGROUND:Chlamydomonas reinhardtii is the model organism that serves as a reference for studies in algal genomics and physiology. It is of special interest in the study of the evolution of regulatory pathways from algae to higher plants. Additionally, it has recently gained attention as a potential source for bio-fue...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2564-y
更新日期:2016-03-12 00:00:00
abstract:BACKGROUND:Controlling and managing the breeding of bluefin tuna (Thunnus spp.) in captivity is an imperative step towards obtaining a sustainable supply of these fish in aquaculture production systems. Germ cell transplantation (GCT) is an innovative technology for the production of inter-species surrogates, by transp...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2397-8
更新日期:2016-03-10 00:00:00
abstract:BACKGROUND:Chemical bioavailability is an important dose metric in environmental risk assessment. Although many approaches have been used to evaluate bioavailability, not a single approach is free from limitations. Previously, we developed a new genomics-based approach that integrated microarray technology and regressi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2541-5
更新日期:2016-03-08 00:00:00
abstract:BACKGROUND:Aluminium (Al) toxicity is the main factor limiting the crop production in acid soils and barley (Hordeum vulgare L.) is one of the most Al-sensitive of the small-grained cereals. The major gene for Al tolerance in barley is HvAACT1 (HvMATE) on chromosome 4H which encodes a multidrug and toxic compound extru...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2551-3
更新日期:2016-03-05 00:00:00
abstract:BACKGROUND:Clostridium botulinum is a diverse group of bacteria characterized by the production of botulinum neurotoxin. Botulinum neurotoxins are classified into serotypes (BoNT/A-G), which are produced by six species/Groups of Clostridia, but the genetic background of the bacteria remains poorly understood. The purpo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2502-z
更新日期:2016-03-03 00:00:00
abstract:BACKGROUND:The phytoflagellated protozoan, Euglena gracilis, has been proposed as an attractive feedstock for the accumulation of valuable compounds such as β-1,3-glucan, also known as paramylon, and wax esters. The production of wax esters proceeds under anaerobic conditions, designated as wax ester fermentation. In s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2540-6
更新日期:2016-03-03 00:00:00
abstract:BACKGROUND:Non-coding RNAs (ncRNAs), which perform diverse regulatory roles, have been found in organisms from all superkingdoms of life. However, there have been limited numbers of studies on the functions of ncRNAs, especially in nonmodel organisms such as Kluyveromyces marxianus that is widely used in the field of i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2474-z
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:Propionibacterium acnes and Staphylococcus epidermidis live in close proximity on human skin, and both bacterial species can be isolated from normal and acne vulgaris-affected skin sites. The antagonistic interactions between the two species are poorly understood, as well as the potential significance of bac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2489-5
更新日期:2016-02-29 00:00:00